![]() (A) Coronal section showing striatal Ki67 + (red) and DCX + (white) cells densely packed at the lesion border (yellow dashed line). For instance, we previously demonstrated that clusters of proliferating cells with features of transient amplifying progenitors (TAPs) produce neurons in the striatum of rabbits ( Luzzati et al., 2006) and in a mouse model of striatal degeneration ( Luzzati et al., 2011b). Nonetheless, examples of parenchymal neurogenesis are emerging ( Bi et al., 2011 Luzzati et al., 2006,, 2011b Ohira et al., 2010). ![]() ![]() The adult brain parenchyma has been generally considered gliogenic and not permissive for the activity of neuronal progenitors ( Lim et al., 2000 Ninkovic and Götz, 2013 Shihabuddin et al., 2000). However, whether parenchymal astrocytes can spontaneously generate neurons in vivo is unclear ( Dimou and Götz, 2014). ![]() Parenchymal astrocytes can become neurogenic in vitro when isolated from the lesioned neocortex ( Buffo et al., 2008 Sirko et al., 2013) or in vivo after overexpression of specific transcription factors ( Niu et al., 2013). In adult neurogenic niches, astrocytic cells produce neurons throughout life ( Fuentealba et al., 2012).
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